Mental Health & Pregnancy · 2026 Research

Your mental health medication matters — especially during pregnancy.

New research shows that stopping antidepressants during pregnancy can significantly increase the risk of a mental health crisis. Here's what you need to know.

About the Research

What did researchers find?

Scientists at the University of Pennsylvania studied nearly 4,000 pregnant patients who all had a diagnosis of depression or anxiety and were taking an antidepressant (SSRI or SNRI) before pregnancy.

🏥 University of Pennsylvania
👩 3,983 patients studied
📅 Published February 2026
🔬 SMFM Annual Meeting
Key Finding

The risk is nearly double.

higher risk of a mental health emergency for patients who stopped their antidepressant during pregnancy

Risk was highest in the 1st and 9th months of pregnancy — times that are already emotionally intense for many people.

Why It Matters

Untreated depression during pregnancy carries real risks — for you and your baby.

For you

Increased risk of suicide, hospitalization, and other mental health crises during and after pregnancy.

For your baby

Untreated depression is linked to preterm birth, preeclampsia, and low birth weight.

Mental health disorders are the leading cause of maternal death in the United States. Your mental health is not separate from your pregnancy health — it is your pregnancy health.

Safety Information

Are antidepressants safe to take during pregnancy?

Current evidence shows that SSRI and SNRI antidepressants are not associated with:

✓ Birth defects
✓ Fetal growth problems
✓ Long-term developmental issues

Every pregnancy is different. Talk openly with your doctor about the risks and benefits for you specifically. This is a shared decision — and you should be fully part of it.

From the Experts

A message from the researchers

"This work underscores the need to take pregnant patients' mental health seriously and to offer the full range of treatment options — including medications when clinically appropriate."

— Dr. Kelly B. Zafman, MD, MSCR
Maternal-Fetal Medicine, Hospital of the University of Pennsylvania

You deserve to have every option available to you. Stopping medication should never feel like something you have to do just because you're pregnant — talk to your provider first.

Your Next Steps

What can you do right now?

🩺

Talk to your OB or MFM specialist

Never stop or change your medication without guidance from your healthcare team.

💬

Be honest about how you're feeling

Tell your provider if you're feeling low, anxious, or overwhelmed — even between appointments.

🤝

Ask about all your options

Medication, therapy, and other supports can often be used together. You don't have to choose.

If you need support now

  • Postpartum Support International: 1-800-944-4773
  • 988 Suicide & Crisis Lifeline: Call or text 988
  • Crisis Text Line: Text HOME to 741741